Nonalcoholic Fatty Liver Disease - 1686 Words

Nonalcoholic fatty liver disease (NAFLD) is defined as accumulation of lipids, mainly triglycerides, due to causes other than viruses, alcohol, or genetics. The disease covers a wide spectrum of status, including simple steatosis, steatohepatitis, and cirrhosis, and is closely related to dyslipidemia, obesity, insulin resistance, and type 2 diabetes mellitus.1 Prevalence of NAFLD has been increasing gradually because of changes in lifestyles such as insufficient physical activities and westernized diet. NAFLD may be asymptomatic, but can be problematic as it is associated with other chronic diseases, including cardiovascular diseases and diabetes. Moreover, in some studies, it is shown to elevate mortality. Various tools are available for diagnosis of NAFLD, but some limitations do exist. For example, using hepatic ultrasound or computed tomography (CT) scan to screen asymptomatic patients is considered cost-ineffective, especially in mass screening. Laboratory tests necessarily involve an invasive procedure (i.e. drawing blood). Moreover, these tools cannot be accessed conveniently by non-practitioners, the fact being an obstacle for lay people to be involved in mass screening of NAFLD. The aforementioned reasons call for development of a new, easy-to-use model for screening NAFLD. In fact, however, there have been few simple, noninvasive and cost-effective systems that can predict NAFLD. Our group once developed a simple self-assessment scoring model for screeningShow MoreRelatedNonalcoholic Fatty Liver Disease Essay1285 Words   |  6 PagesNonalcoholic Fatty Liver Disease, one of the most common liver disorders, can have several causes, such as congenital, pharmaceutical, or other miscellaneous sources, but the most clinically important etiology is metabolic disorder. Metabolic Disorder, also known as syndrome X, is a collection of symptoms that occur in clusters, and cause a patient to have a higher risk of heart disease, stroke, and diabetes. Metabolic syndrome has several hallmark signs. Many of these conditions can occur aloneRead MoreNonalcoholic Fatty Liver Disease (Nafld), Is A Form Of1212 Words   |  5 PagesNonalcoholic fatty liver disease (NAFLD), is a form of chronic liver disease ranging in severity from simple fat infiltration (steatosis) to an advanced form, nonalcoholic steatohepatitis (NASH, steatosis with liver inflammation) with subsequent progression to fibrosis.1 The relationship between gut flora and the development of NAFLD have been under study for almost the last decade. Uncontrolled growth of gut bacteria and translocation of gut microorganisms from the intestinal lumen predispose patientsRead MoreThe Effect Of Nonalcoholic Fatty Li ver Disease ( Nafld ) Essay1776 Words   |  8 PagesAbstract Background: Nonalcoholic fatty liver disease (NAFLD) is a metabolic disease commonly associated with obesity, type 2 diabetes, and inflammation-all features of insulin resistant syndrome. However, very limited data are available regarding the association of subclinical inflammation and insulin resistance with NAFLD in a prediabetic state. We, therefore, conducted the study to assess this relationship among this population. Methods: We studied a cross-sectional analytical design of 140 [male/femaleRead MoreThe Effects Of Nonalcoholic Fatty Liver Disease On Obese Pediatric Population985 Words   |  4 PagesNonalcoholic Fatty Liver Disease in Obese Pediatric Population In the United States, increasing numbers of obesity in pediatric population is major concern in health care field. According to Center of Disease Control (CDC), in the United States obesity in children from 6 to 11 years of age in 1980 was seven percent. This rate about three times by 2008, to 20%. Adolescents’ obesity from 12 to 19 years of age in 1980 was five percent and this correspondingly rate more than three times byRead MoreLiver Biopsy Essay802 Words   |  4 PagesChronic liver diseases and liver biopsy. Chronic liver diseases encompass many different causes, including viral infections, nonalcoholic fatty liver disease (NAFLD), alcohol abuse, primary sclerosing cholangitis, primary hemochromatosis, and autoimmune disease. All of these precipitate chronic damage to the liver via necroinflammation and subsequent cellular injury and accumulation of extracellular matrix (ECM) proteins distorting the hepatic architecture by forming hepatic fibrosis with abnorm alRead MoreObesity and Non Alcoholic Fatty Liver Disease Essay1787 Words   |  8 PagesThis disease was uncommon in the old days because it was unusual to accumulate enough fat to hurt livers. However, many people in the United States are now suffering from NAFLD and NASH. Before 1998, there was no case of NASH heard. In contrast, a statistics from a website called Partners In Liver Wellness provides an alarming information. The site says, â€Å"As a consequence of the on-going obesity epidemic in the U.S., fatty liver is a very common disorder with an estimated two thirds of obese adultsRead MoreAlcohol Consumption And Metabolic Syndrome1361 Words   |  6 PagesBoth alcohol consumption and metabolic syndrome are risk factors for development of fatty liver diseases with similar pathology which ultimately can result in development of liver cancer.3, 4, 24-273, 4, 23-26 Using a two-stage mouse model in which tumor initiation by DEN was followed by a 35% high fat diet, we have pr eviously reported increased tumor incidence, suggestive of a diet-related promotional effect.11 Consistent with these findings, in the current study, we observed increased adenomaRead MoreIs Withaferin A, A Magic Bullet For Metabolic Syndrome?1435 Words   |  6 PagesLPS induced lung injury etc 31-34. Recently, Withaferin A also reported as a ligand for nuclear receptor LXR-ÃŽ ±35. This LXR-ÃŽ ± is a well-known nuclear receptor with various functions in metabolism and diseases including cholesterol, fatty acid, and glucose homeostasis in nonalcoholic fatty liver disease 36-40. Here, Withaferin A may regulate all these functions by inducing or suppressing genes through this nuclear receptor mediated transcriptional activation 41-43. All these properties of WithaferinRead MoreApplication of Statistics in Pharmaceutical Industry3871 Words   |  16 Pagespharmaceutical is its application in clinical trials wherein the efficacy of one drug is compared with the other. Clinical trial: a nutritional supplement Viusid, in combination with diet and exercise, in patients with nonalcoholic fatty liver disease SUMMARY Background Nonalcoholic fatty liver disease (NAFLD) is a significant health problem for which there is no universally accepted pharmacological treatment. The combination of weight loss and antioxidant drugs to ameliorate insulin resistance and improveRead MoreFatty Liver Disease Case Study1009 Words   |  5 Pageswere selected for this paper. First trial focuses on the management of fatty liver disease with vitamin E and C combined compared to usrodeoxycholic acid treatment. Second trial focuses on only vitamin E, pioglitazone, or placebo on NAFLD patients. Third trials focuses on the treatment of nonalcoholic steatohepatitis with vitamin E and vitamin C combined. Final trial focuses on pioglitazone, vitamin E, or placebo for nonalcoholic steatohepatitis, similar to the second trial. First trial had patients